Scientific Publications

Clinical Trials and Research Base using XAI-MEDICA Equipment


Scientific and Methodological Foundation of XAI-MEDICA Systems

The efficiency of diagnostic systems CardioLab, ReoCom, NeuroCom and SpiroCom is proven by numerous clinical studies, doctoral dissertations, and 30 years of implementation experience. Our devices are used for fundamental research in vegetology, cardiology, and neurophysiology.

  • Vegetology: HRV analysis for adaptation assessment.
  • Hemodynamics: Endothelial function and vascular tone studies.
  • Neurophysiology: EEG patterns and neurodynamics.
  • Pulmonology: COPD monitoring and respiratory function analysis.

* Note: Some links lead to external repositories; full-text availability depends on publishers' policies. In the absence of an English translation, publications are available in the original language only.

📑 Table of Contents

CardioLab - Electrocardiography and HRV

Equipment Description
1. Scientific Study: Effect of caffeine on heart rate variability in doxorubicin cardiomyopathy
Experimental study, 2025. In press. Analysis via CardioLab.
2. Hypodynamia and gonadectomy: impact on HRV parameters in experimental rats
Experimental Physiology Group, 2025. Pre-print. Research on adaptive capabilities.
3. Nazarenko V. I., Berestovskyi O. S., Moroz H. Z. Heart rate variability in COVID-19 patients with different levels of cardiovascular risk
Wiadomości Lekarskie, 2022, Vol. 75, Iss. 4, pp. 845-850. HRV study in COVID-19.
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4. Kudiy L. I., Varetska O. V., Kudiy S. V. Reliability of "Rytm" software for heart rate variability analysis
Journal of Physical Education and Sport, 2020, Vol. 20 (6), Art 427, pp. 3154-3160. "Rytm" SW validation.
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5. Kulbashna N. I., Polyakov A. S. Changes in the stress index of a passenger car driver when moving in a dense traffic flow
Transport Technologies, 2020. HRV study using CARDIOCOM.
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6. Kentesh O. P., Nemesh M. I. Functional state of the autonomic nervous system depending on the body composition
Wiadomości Lekarskie, 2018, Vol. 71, Iss. 2, pp. 312-316.
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7. Tymoshchuk O. V. Diagnosis of adaptation disorders in children with chronic gastroduodenitis based on HRV indicators
Child's Health, 2016, No. 7 (75). Autonomic status assessment.
8. Syvolap V. D. Electrocardiographic diagnostics and hemodynamic parameters in acute myocardial infarction
Zaporozhye Medical Journal, 2013, No. 2 (77), pp. 45-48.
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9. Syvolap V. V., Kyselov S. M., Apolikhin O. I. Structural-geometric and functional assessment of myocardium in patients with stage II hypertension
Zaporozhye Medical Journal, 2012, No. 1 (70), pp. 34-37. CardioLab application.
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10. Dovgan O. P. Spectral analysis of heart rate variability under different modes of artificial lung ventilation
Scientific Works of TNTU. Research using CARDIOCOM.
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11. Polyakov A. S. Automated processing of biomedical signals in cardiography
Collection of scientific papers. CARDIOCOM algorithm analysis.
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ReoCom - Rheography and Endothelial Function

Equipment Description
1. Lutsyk N. Structural-geometric and functional assessment of the myocardium in patients with hypertension
Scientific Paper, TNTU 2021. Rheographic analysis application.
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2. Patent No. 121689: Method for assessing central aortic pressure
Registered in the State Patent Register of Ukraine, 10.07.2020.
Open patent (PDF)
3. Patent No. 120800: Method for measuring blood pressure
Registered in the State Patent Register of Ukraine, 10.02.2020.
Open patent (PDF)
4. Patent No. 118939: Method for assessing the function of arterial vessel endothelium
Registered in the State Patent Register of Ukraine, 25.03.2019.
Open patent (PDF)
5. Study of endothelial regulation of vascular tone (Parts 1 and 2)
Methodological guide, 2014. XAI-Medica. Step-by-step guide.
Part 1 Part 2
6. Fedorov A. A. Functional state of endothelium in patients with vasospastic angina
Journal of Cardiovascular Diseases, 2014. Clinical study.
7. Penelova Z. V. Features of psychophysiological reaction when using the "ReoCom-stress" complex
Zaporozhye Medical Journal, 2013, No. 4 (79).
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8. Blood pressure in symmetric vascular basins: rheographic assessment
Methodological article, 2012. Measurement protocol with ReoCom.
Read online
9. Assessment of cerebral blood flow volumetric velocity (according to Paleev)
XAI-Medica Methodological guide, 2008. Kharkiv.
Read Methodology
10. Selection of informational parameters in rheographic assessment of endothelial function in a reactive hyperemia test
XAI-Medica Methodological Recommendations, 2007. Kharkiv.
Read Methodology
11. Pulse wave velocity and elastic properties of arterial vessels
Methodological development. Arterial stiffness assessment.
Read online
12. Assessment of the vascular system based on rheographic measurement results
Scientific and methodological review. Data interpretation algorithms.
Read online
13. New approaches to vascular system assessment based on rheographic studies
Methodological materials. Application in clinical practice.
Read online
14. Rheographic assessment of peripheral circulation (Full archive)
XAI-Medica Collection. Methods and results.
Download PDF archive

NeuroCom - Electroencephalography

Equipment Description
1. Maruschak P., Lutsyk N. Comparison of the accuracy of machine learning algorithms for brain-computer interaction
TNTU Journal, 2021. Application of NeuroCom complexes.
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2. Savenko O. Development of software for neuromarketing based on AI and data science
TNTU Open Archive, 2020. EEG research based on XAI-MEDICA equipment.
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3. Tukaiev S. A. EEG frequencies pattern as brain signature of emotional burnout
International Journal of Physiology, 2018. Emotional burnout diagnosis.
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4. Yukhymenko O. V. Features of EEG patterns in individuals with different functional mobility of nervous processes
PhD Thesis. Taras Shevchenko National University of Kyiv, 2015. NeuroCom research.
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5. Shpenkov O. O. Changes in the electrical activity of the brain when listening to audio stimuli
Bulletin of Cherkasy University, 2014. EEG data analysis.
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6. Kryzhanovsky S. A. Correlation between activity efficiency and EEG parameters
Neurophysiology, 2009. Fundamental study.

SpiroCom - Spirometry

Equipment Description
1. Tyshchenko V., Singayevsky S. Enhancing respiratory function through Yoga and Pilates in women aged 45-50
Pedagogy of Physical Culture and Sports, 2024, 28(5), pp. 449-455. Study via SpiroCom.
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2. Feshchenko Yu. I. Monitoring of respiratory function in patients with COPD using digital complexes
Asthma and Allergy, 2020, No. 3. Clinical efficiency.
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Combined Studies

1. Kentesh O. P. Impact of autonomic dysfunction on the state and function of the endothelium in young individuals (CardioLab + ReoCom)
PhD Thesis. Uzhhorod National University, 2018.
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2. Spirina I. D. Psychophysiological aspects of adaptation and the functional state of the vascular system
Journal of Psychiatry and Psychopharmacotherapy, 2013. Comprehensive diagnostics.

Scientific publications demonstrate the clinical effectiveness of XAI-MEDICA equipment.

Contact for Research Cooperation:
Email: research@xai-medica.com